Risk Factors and Prevention of Iron Deficiency Anemia in Children At Development Country

Authors

  • Reqgi First Trasia Departemen Parasitologi, Fakultas Kedokteran, Universitas Sultan Ageng Tirtayasa

Keywords:

Faktor risiko, pencegahan, anemia, anak, kekurangan zat besi

Abstract

Latar Belakang: Di negara berkembang, penyebab  anemia, yaitu infeksi parasit seperti malaria, kekurangan zat gizi, penyakit kronis, hemoglobinopati, dan keracunan timbal.  Anemia pada ibu di negara dengan sumber daya yang rendah dikaitkan dengan berat badan lahir rendah (BBLR), peningkatan kematian perinatal, dan penurunan produktivitas kerja.rendah (BBLR), peningkatan kematian perinatal, dan

Motode: Penelusuran kepustakaan dilakukan melalui Pubmed dan Google scholar untuk mendapatkan artikel yang relevan.

Hasil: Mempertahankan keseimbangan zat besi yang normal dalam keadaan infeksi parasit merupakan sebuah tantangan, karena makanan kaya zat besi dengan bioavailability yang baik ialah berasal dari hewan, yang mana mahal dan/atau persediaannya terbatas. Terlepas dari jarangnya mengkonsumsi daging, ketidakcukupan asupan vitamin C dan diet kaya akan inhibitor penyerapan zat besi merupakan faktor risiko tambahan yang penting pada anemia kekurangan zat besi di negara dengan penghasilan rendah

Kesimpulan: Fortifikasi zat besi di rumah pada makanan tambahan dengan bubuk mikronutrien telah terbukti efektif mengurangi risiko kekurangan zat besi dan ADB pada bayi dan anak kecil di negara berkembang, tetapi dikaitkan dengan perubahan yang tidak menguntungkan pada bakteri saluran cerna dan induksi peradangan usus yang dapat menyebabkan diare  dan peningkatan risiko rawat inap. Di negara industri, ADB lebih sering terjadi pada bayi dengan usia lebih dari enam bulan.

References

WHO. (2005).Worldwide prevalence of anaemia 1993-2005: WHO global database on anaemia, Edited by: de Benoist B, McLean E, Egli I, Cogswell M. WHO Library Cataloguing-in-Publication Data. ISBN 9789241596657. https://www.who.int/nutrition/publications/micronutrients/anaemia_iron_deficiency/ 9789241596657/en/

Pasricha SR, Drakesmith H, Black J, Hipgrave D, Biggs BA. (2013). Control of iron deficiency anemia in low- and middle-income countries. Blood;121(14): 2607-2617. https://doi.org/10.1182/blood-2012-09-453522 PMid:23355536

Shaw JG, Friedman JF. (2011). Iron deficiency anemia: focus on infectious diseases in lesser developed countries. Anemia:260380. https://doi.org/10.1155/2011/260380 PMid:21738863 PMCid:PMC3124144

Rahman MM, Abe SK, Rahman MS, Kanda M, Narita S, Bilano V, Ota E, Gilmour S, Shibuya K. (2016). Maternal anemia and risk of adverse birth and health outcomes in low- and middle-income countries: systematic review and meta- analysis. Am J Clin Nutr;103(2):495-504. https://doi.org/10.3945/ajcn.115.107896 PMid:26739036

Bailey RL, West K.P. Jr, Black RE. (2015). The epidemiology of global micronutrient deficiencies. Ann Nutr Metab. 2015;66 (Suppl 2):22-33. https://doi.org/10.1159/000371618 PMid:26045325

Gupta PM, Perrine CG, Mei Z, Scanlon KS. (2016) Iron, anemia, and iron deficiency anemia among young children in the United States. Nutrients.;8(6). pii: E330. https://doi.org/10.3390/nu8060330 PMid:27249004 PMCid:PMC4924171

Eussen S, Alles M, Uijterschout L, Brus F, van der Horst-Graat J. (2015). Iron intake and status of children aged 6-36 months in Europe: a systematic review. Ann Nutr Metab;66(2-3):80-92.https://doi.org/10.1159/000371357 PMid:25612840

Armitage AE, Moretti D. (2019) The importance of iron status for young children in low- and middle-income countries: a narrative review. Pharmaceuticals (Basel);12(2). pii: E59. https://doi.org/10.3390/ph12020059 PMid:30995720 PMCid:PMC6631790

Swinkels H, Pottie K, Tugwell P, Rashid M, Narasiah L; Canadian Collaboration for Immigrant and Refugee Health (CCIRH). (2011). Development of guidelines for recently arrived immigrants and refugees to Canada: Delphi consensus on selecting preventable and treatable conditions. CMAJ;183(12):E928-932.https://doi.org/10.1503/cmaj.090290 PMid:20547714 PMCid:PMC3168668

GBD (2016). Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet;388(10053):1545- 1602.https://doi.org/10.1016/S0140-6736(16)31678-6

Baker RD, Greer FR. (2010). Committee on Nutrition American Academy of Pediatrics. Diagnosis and prevention of iron deficiency and irondeficiency anemia in infants and young children (0-3 years of age). Pediatrics. 2010;126(5):1040-1050.https://doi.org/10.1542/peds.2010-2576 PMid:20923825

Jang HN, Yoon HS, Lee EH. (2019). Prospective case control study of iron deficiency and the risk of febrile seizures in children in South Korea. BMC Pediatr. 2019;19(1):309. https://doi.org/10.1186/s12887-019-1675-4 PMid:31484495 PMCid:PMC6724315

Tomoum H, Habeeb N, Elagouza I, Mobarez H. (2018). Paediatric breathholding spells are associated with autonomic dysfunction and iron deficiency may play a role. Acta Paediatr;107(4):653-657. https://doi.org/10.1111/apa.14177 PMid:29210110

Howard H, Kamat D. (2018). Restless legs syndrome in children. Pediatr Ann;47(12):e504-506.https://doi.org/10.3928/19382359-20181114-02 PMid:30543380

Houston BL, Hurrie D, Graham J, Perija B, Rimmer E, Rabbani R, Bernstein CN, Turgeon AF, Fergusson DA, Houston DS, Abou-Setta AM, Zarychanski R. (2018). Efficacy of iron supplementation on fatigue and physical capacity in non- anaemic iron-deficient adults: a systematic review of randomised controlled trials. BMJ Open;8(4):e019240. https://doi.org/10.1136/bmjopen-2017-019240 PMid:29626044 PMCid:PMC5892776

Brotanek JM, Gosz J, Weitzman M, Flores G. (2008). Secular trends in the prevalence of iron deficiency among U.S. toddlers, 1976-2002. Arch Pediatr Adolesc Med;162(4):374-381. https://doi.org/10.1001/archpedi.162.4.374 PMid:18391147

De Andrade Cairo RC, Rodrigues Silva L, Carneiro Bustani N, Ferreira Marques CD. (2014). Iron deficiency anemia in adolescents; a literature review. Nutr Hosp;29(6): 1240-1249.

Powers JM, Buchanan GR. (2019). Disorders of iron metabolism: new diagnostic and treatment approaches to iron deficiency. Hematol Oncol Clin North Am.;33:393-408. https://doi.org/10.1016/j.hoc.2019.01.006 PMid:31030809

Zhang AS, Enns CA. (2009) Iron homeostasis: recently identified proteins provide insight into novel control mechanisms. J Biol Chem.;284(2):711-715. https://doi.org/10.1074/jbc.R800017200 PMid:18757363 PMCid:PMC2613612

Teucher B, Olivares M, Cori H. (2004). Enhancers of iron absorption: ascorbic acid and other organic acids. Int J Vitam Nutr Res;74(6):403-419. https://doi.org/10.1024/0300-9831.74.6.403 PMid:15743017

Ginzburg YZ. (2019) Hepcidin-ferroportin axis in health and disease. Vitam Horm.;110:17-45. https://doi.org/10.1016/bs.vh.2019.01.002 PMid:30798811

Roth MP, Meynard D, Coppin H. (2019) Regulators of hepcidin expression. Vitam Horm. ;110:101-129. https://doi.org/10.1016/bs.vh.2019.01.005 PMid:30798807

Weiss G, Ganz T, Goodnough LT. (2019) Anemia of inflammation. Blood;133(1):40-50.

https://doi.org/10.1182/blood-2018-06-856500 PMid:30401705 PMCid:PMC6536698

Olivares M, Walter T, Hertrampf E, Pizarro F. (2000). Anaemia and iron deficiency disease in children. Br Med Bull;55(3):534-543. https://doi.org/10.1258/0007142991902600 PMid:10746344

Lynch S, Stoltzfus R, Rawat R. (2007). Critical review of strategies to prevent and control iron deficiency in children. Food Nutr Bull.;28(Suppl 4):S610- 620. https://doi.org/10.1177/15648265070284S413 PMid:18297898

Zlotkin S, PenaRosas JP, Velazquez FB. (2018). WHO Department of Nutrition for Health and Development. Multiple Micronutrient Powders for Pointof-Use Fortification of Foods Consumed by Infants and Children 6-23 Months of Age and Children Aged 2-12 Years. https://www.who.int/selection_medicines/committees/expert/22/applications/s10.1_ micronutrient-powders.pdf?ua=1

Unicef. (2019). Multiple micronutrient pdr,sach./PAC-30.

Suchdev PS, Jefferds MED, Ota E, da Silva Lopes K, De-Regil LM. (2020). Home fortification of foods with multiple micronutrient powders for health and nutrition in children under two years of age. Cochrane Database Syst Rev. 2020;2:CD008959. https://doi.org/10.1002/14651858.CD008959.pub3 PMid:32107773

Weiss G. (2015). Dietary iron supplementation: a proinflammatory attack on the intestine? Gut. ;64(5):696-697. https://doi.org/10.1136/gutjnl-2014-308147 PMid:25331454

Jaeggi T, Kortman GA, Moretti D, Chassard C, Holding P, Dostal A, Boekhorst J, Timmerman HM, Swinkels DW, Tjalsma H, Njenga J, Mwangi A, Kvalsvig J, Lacroix C, Zimmermann MB. (2015). Iron fortification adversely affects the gut microbiome, increases pathogen abundance and induces intestinal inflammation in Kenyan infants. Gut;64(5):731- 742. https://doi.org/10.1136/gutjnl-2014-307720 PMid:25143342

Wieringa FT. (2017). Micronutrient powders to combat anemia in young children: does it work? BMC Med;15(1):99. https://doi.org/10.1186/s12916-017-0867-8 PMid:28490333 PMCid:PMC5425983

Merryweather-Clarke AT, Pointon JJ, Shearman JD, Robson KJ. (2000). Global prevalence of putative haemochromatosis mutations. J Med Genet;34(4):275-278. https://doi.org/10.1136/jmg.34.4.275 PMid:9138148 PMCid:PMC1050911

Wood M.J., Skoien R, Powell LW. (2009). The global burden of iron overload. Hepatol Int. ;3(3):434-444. https://doi.org/10.1007/s12072-009-9144-z PMid:19669241 PMCid:PMC2748371

Burke RM, Leon JS, Suchdev PS. (2014) Identification, prevention and treatment of iron deficiency during the first 1000 days. Nutrients.;6(10):4093-4114. https://doi.org/10.3390/nu6104093 PMid:25310252 PMCid:PMC4210909

Parkin PC, DeGroot J, Maguire JL, Birken CS, Zlotkin S. (2016). Severe irondeficiency anaemia and feeding practices in young children. Public Health Nutr;19(4):716-722. https://doi.org/10.1017/S1368980015001639 PMid:26027426

Annibale B, Marignani M, Monarca B, Antonelli G, Marcheggiano A, Martino G, Mandelli F, Caprilli R, Delle Fave G. (2000) Reversal of iron deficiency anemia after Helicobacter pylori eradication in patients with asymptomatic gastritis. Ann Intern Med;131(9): 668-672. https://doi.org/10.7326/0003-4819-131-9-199911020-00006 PMid:10577329

Loukas A, Hotez PJ, Diemert D, Yazdanbakhsh M, McCarthy JS, Correa- Oliveira R, Croese J, Bethony JM. (2016). Hookworm infection. Nat Rev Dis Primers;2:16088. https://doi.org/10.1038/nrdp.2016.88 PMid:27929101

Akin M, Sarbay H, Guler S, Balci YI, Polat A. (2016). Response to parenteral iron therapy distinguish unexplained refractory iron deficiency anemia from iron- refractory iron deficiency anemia. Int J Lab Hematol.;38:167-171. https://doi.org/10.1111/ijlh.12462 PMid:26818204

Heeney MM, Finberg KE. (2014) Iron-refractory iron deficiency anemia (IRIDA). Hematol Oncol Clin North Am.;28(4):637-652, v. https://doi.org/10.1016/j.hoc.2014.04.009 PMid:25064705

Garofalo M, Abenhaim HA. (2012) Early versus delayed cord clamping in term and preterm births: a review. J Obstet Gynaecol Can.;34(6):525- 531. https://doi.org/10.1016/S1701-2163(16)35268-9

Ziegler EE. (2011). Consumption of cow's milk as a cause of iron deficiency in infants and toddlers. Nutr Rev.;69 (Suppl 1):S37-42. https://doi.org/10.1111/j.1753-4887.2011.00431.xPMid:22043881

Downloads

Published

2021-12-25

How to Cite

Trasia, R. F. (2021). Risk Factors and Prevention of Iron Deficiency Anemia in Children At Development Country. JoPHIN: Journal of Public Health and Industrial Nutrition, 1(1), 27–35. Retrieved from https://journal.tritunas.ac.id/index.php/JoPHIN/article/view/18

Issue

Section

Articles